Tasosartan, CAS 145733-36-4

Formulation: A crystalline solid

Formal Name: 5,8-dihydro-2,4-dimethyl-8-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-pyrido[2,3-d]pyrimidin-7(6H)-one

Purity: ≥98%

Formula Markup: C23H21N7O

Formula Weight: 411,5

Shelf life (days): 1460

CAS Number: 145733-36-4

Notes: Tasosartan is an angiotensin II type 2 (AT2) receptor antagonist (IC50 = 1.2 nM in rat adrenal gland membranes).{48831} It also binds to the AT1 receptor (Ki = 46.6 nM in rat liver epithelial cells).{48832} Tasosartan (3 mg/kg, intraduodenally) reduces the AT2-induced pressor response in rats.{48833} It also decreases mean arterial pressure in a rat model of hypertension induced by renal artery constriction when administered intragastrically or intravenously at doses of 1 and 3 mg/kg.{48831}

• SKU: CAY29495-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29495-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK