Formulation: A solid
Formal Name: 8-(2-methylalanine)-35-(2-methylalanine)-36-L-argininamide-7-36-glucagon-like peptide I (human), acetate
Purity: ≥98%
Formula Markup: C152H232N40O45 • XC2H4O2
Formula Weight: 3339,7
Shelf life (days): 1460
CAS Number: 1022150-16-8
Notes: Taspoglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R; Ki = 1.1 nM for the human receptor).{67869} It induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide (1 mg/animal per week) decreases blood levels of glucose and increases blood levels of insulin in an oral glucose tolerance test in Zucker diabetic obese rats. It reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model.{67870}