Formulation: A crystalline solid
Formal Name: 2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C26H40D4NO7S • Na
Formula Weight: 541,7
Shelf life (days): 730
Notes: Tauro-β-muricholic acid-d4 (TβMCA-d4) is intended for use as an internal standard for the quantification of TβMCA (Item No. 20289) by GC- or LC-MS. TβMCA is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 µM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid (Item No. 20287).{33771} TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.{33771,33772} TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.{33770}
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