Formulation: A crystalline solid
Formal Name: 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid, ethyl ester
Purity: ≥98%
Formula Markup: C21H21NO2S
Formula Weight: 351,5
Shelf life (days): 1460
CAS Number: 118292-40-3
Notes: Tazarotene is a retinoid prodrug of tazarotenic acid (Item No. 21367).{33614} It is metabolized by esterases in vivo to its active free acid form. Tazarotene (1 μM) inhibits proliferation of and collagen synthesis by human dermal fibroblasts in vitro.{41677} It also downregulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation and upregulates tazarotene-induced gene 1 (TIG1) and TIG2 in patient-derived psoriatic lesion samples following topical administration.{41678} Tazarotene (0.1% per day, topical) induces complete reduction in skin utricle diameter in the Rhino mouse, which is a model used to test retinoid activity because its skin contains keratinized pilosebaceous structures.{41679} It also decreases basal cell carcinoma number and size in a Ptch1+/- mouse model of ultraviolet- or ionizing radiation-induced skin cancer when administered topically at a dose of 0.1% per day.{41680} Formulations containing tazarotene have been used in the treatment of psoriasis, acne, and sun-damaged skin.
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