TBPB, CAS 634616-95-8

Formulation: A crystalline solid

Formal Name: 1,3-dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one

Purity: ≥98%

Formula Markup: C25H32N4O

Formula Weight: 404,6

Shelf life (days): 1460

CAS Number: 634616-95-8

Notes: TBPB is an allosteric agonist of M1 muscarinic acetylcholine receptors (mAChRs; EC50 = 158 nM in CHO-K1 cells expressing rat recombinant receptors).{45505} It is selective for M1 over M2-5 receptors at concentrations up to 10 μM. TBPB (3 μM) potentiates NMDA-evoked currents in CA1 pyramidal cells. It increases production of the non-amyloidogenic amyloid precursor protein (APP) cleavage products APPsα and CTFα in PC12 cells overexpressing the human M1 receptor and APP when used at a concentration of 1 μM. TBPB decreases amphetamine-induced hyperlocomotion in a rat model that is predictive of antipsychotic-like activity.

• SKU: CAY22943-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22943-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK