TC-FPR 43, CAS 903895-98-7

Formulation: A crystalline solid

Formal Name: N-(4-chlorophenyl)-N′-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea

Purity: ≥98%

Formula Markup: C20H21ClN4O2

Formula Weight: 384,9

Shelf life (days): 1460

CAS Number: 903895-98-7

Notes: TC-FPR 43 is an agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).{52690,52691} TC-FPR 43 induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner.{52691} TC-FPR 43 inhibits migration of polymorphonuclear (PMN) neutrophils induced by fMLP (Item No. 21495) or IL-8 with IC50 values of 0.64 and 0.24 µM, respectively.{52690} It also reduces ear swelling induced by prostaglandin E2 (PGE2; Item No. 14010) and leukotriene B4 (LTB4; Item No. 20110) in mice when administered at a dose of 50 mg/kg.

• SKU: CAY29804-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29804-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK