TCMCB07 (trifluoroacetate salt)

Formulation: A solid

Formal Name: N-acetyl-L-norleucyl-L-α-aspartyl-L-prolyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysyl-D-valyl-D-prolinamide, (2→7)-lactam, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C63H87N15O11 • XCF3COOH

Formula Weight: 1230,5

Shelf life (days): 1460

Notes: TCMCB07 is a peptide antagonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (IC50s = 19.5, 0.59, 13.58, and 8.07 nM, respectively, for the human receptors).{72497} It is also an antagonist of dog MC1R, MC3R, MC4R, and MC5R receptors (IC50s = 53.64, 1.46, 7.14, and 11.22 nM, respectively). TCMCB07 (10 mg/kg) increases food intake and body weight in a rat model of LPS-induced cachexia. It increases body weight, muscle mass, blood levels of urea nitrogen, and mean heart rate in dogs with cachexia when administered at a dose of 0.75 mg/kg per day.{72498}

• SKU: CAY41545-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41545-1
• Package Unit: 1 mg
• Quantity Unit: STK