Formulation: A solid
Formal Name: (S)-N-(2-(((S)-6-amino-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-1-oxohexan-2-yl)amino)-2-oxoethyl)-1-(cinnamoyl-L-tyrosyl)pyrrolidine-2-carboxamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C40H49N7O7 • XCF3COOH
Formula Weight: 739,9
Shelf life (days): 1460
Notes: tcY-NH2 is a synthetic peptide antagonist of proteinase-activated receptor 4 (PAR4) that corresponds to amino acids 1-6 of the amino terminal tethered ligand sequence of mouse PAR4.{36396} It inhibits platelet aggregation induced by the PAR4 agonist AYPGKF-NH2 (Item No. 24258) in washed isolated rat platelets (IC50 = 95-190 µM), as well as induces relaxation of isolated rat aortic rings precontracted with phenylephrine and contraction of isolated rat gastric longitudinal muscle strips (EC50s = 64 and 1 µM, respectively). tcY-NH2 (400 µM) inhibits thrombin-induced migration of primary hepatocellular carcinoma (HCC) cells.{67050} It reduces myocardial infarct size as a percentage of the area at risk ex vivo in a isolated rat heart model of ischemia-reperfusion injury.{67051}
English
Deutsch
