Formulation: A solid
Formal Name: 4'-((7'-methyl-1-(methyl-d3)-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C33H27D3N4O2
Formula Weight: 517,6
Shelf life (days): 1460
CAS Number: 1189889-44-8
Notes: Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Item No. 11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM).{20934} It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (Item No. 71740; EC50 = 4.5 μM).{20930} Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.{20932,20931,20933}
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