TG11-77 (hydrochloride), CAS 2550393-38-7

Formulation: A crystalline solid

Formal Name: 2-((4,6-dimethylpyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C23H24N6O • HCl

Formula Weight: 436,9

Shelf life (days): 730

CAS Number: 2550393-38-7

Notes: TG11-77 is a brain-permeable antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 (KB = 9.7 nM).{50985} It is selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors.

• SKU: CAY30188-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30188-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK