TGN 020, CAS 51987-99-6

Formulation: A solid

Formal Name: N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C8H6N4OS

Formula Weight: 206,2

Shelf life (days): 1460

CAS Number: 51987-99-6

Notes: TGN 020 is an aquaporin-4 (AQP4) inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4).{60036} It reduces brain edema and cortical infarction size in a mouse model of transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 200 mg/kg.{60037} TGN 020 (200 mg/kg every 6 hours) reduces bronchoalveolar lavage fluid (BALF) IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury.{60038}

• SKU: CAY30955-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30955-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK