TGR5 Receptor Agonist, CAS 1197300-24-5

Formulation: A crystalline solid

Formal Name: 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide

Purity: ≥98%

Formula Markup: C18H14Cl2N2O2

Formula Weight: 361,2

Shelf life (days): 1460

CAS Number: 1197300-24-5

Notes: TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays).{27533} It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM).{27534} TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose levels in the hepatic portal vein in dogs when administered in combination with glucose.{27533} It also inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively).

• SKU: CAY16291-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16291-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe