Formulation: A crystalline solid
Formal Name: 3,9-dihydro-1,3-di(methyl-d3)-1H-purine-2,6-dione
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C7H2D6N4O2
Formula Weight: 186,2
Shelf life (days): 1460
CAS Number: 117490-39-8
Notes: Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline (Item No. 23760) by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase (PDE; Ki = 100 µM).{41252} It is also an adenosine A1 and A2 receptor antagonist (Ki = 14 µM for both).{41253} Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine (EC40 = 117 µM).{41254} It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
English
Deutsch
