Formulation: A lyophilized powder
Formal Name: L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-L-prolyl-L-asparaginyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-α-glutamyl-L-prolyl-L-phenylalanine, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C81H118N20O23 • XCF3COOH
Formula Weight: 1739,9
Shelf life (days): 1460
Notes: Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the α-thrombin receptor.{38911} It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma.{38919} TRAP-14 (100 μM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary smooth muscle cells 5-fold over baseline.{38911} It increases pulmonary arterial pressure in isolated guinea pig lung when used at a concentration of 1 μM, which is comparable to the effect induced by 10 nM α-thrombin. TRAP-14 also induces contraction of isolated rat aortic rings and increases endothelin-1 (ET-1) levels in a dose-dependent manner, an effect that is reversed by the ETA antagonist BQ-123 and the nitric oxide synthase (NOS) inhibitor L-NNA (Item No. 80220).{38920}
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