Formulation: A solid
Formal Name: 5-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]-pentanoic acid, monosodium salt
Purity: ≥98%
Formula Markup: C19H20ClN2O4S • Na
Formula Weight: 430,9
Shelf life (days): 1460
CAS Number: 115220-11-6
Notes: Tianeptine metabolite MC5 is an active metabolite of the atypical antidepressant tianeptine (Item No. 17561).{43567} It is formed from tianeptine by β-oxidation.{51409} Tianeptine metabolite MC5 selectively induces G protein activation in bioluminescence resonance energy transfer (BRET) assays using HEK293T cells expressing the human μ-opioid receptor (MOR) over the human δ-opioid receptor (DOR; EC50s = 0.454 and >100 µM, respectively).{43567} It decreases immobility in the forced swim test in wild-type mice, but not MOR knockout mice, indicating MOR-dependent antidepressant-like activity when administered at a dose of 30 mg/kg.
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