Formulation: A solid
Formal Name: 5-[(2-chlorophenyl-d4)methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C14H10ClD4NS • HCl
Formula Weight: 304,3
Shelf life (days): 1460
CAS Number: 2932627-17-1
Notes: Ticlopidine-d4 is intended for use as an internal standard for the quantification of ticlopidine (Item No. 20770) by GC- or LC-MS. Ticlopidine is a thienopyridine P2Y12 receptor antagonist.{37611} It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).{37612} It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.{23697} Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.{37613} Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.
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