Formulation: A solid
Formal Name: (1α,2β,4β,5α,7β)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9-methyl-9-(methyl-d3)-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C19H19D3NO4S2 • Br
Formula Weight: 475,4
Shelf life (days): 1460
CAS Number: 1127226-56-5
Notes: Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium (Item No. 15773) by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).{42255} It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).
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