TIP39 (human, bovine) (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-seryl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-alanyl-L-alanyl-L-phenylalanyl-L-arginyl-L-α-glutamyl-L-arginyl-L-alanyl-L-arginyl-L-leucyl-L-leucyl-L-alanyl-L-alanyl-L-leucyl-L-α-glutamyl-L-arginyl-L-arginyl-L-histidyl-L-tryptophyl-L-leucyl-L-asparaginyl-L-seryl-L-tyrosyl-L-methionyl-L-histidyl-L-lysyl-L-leucyl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-alanyl-L-proline, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C202H325N61O54S • XCF3COOH

Formula Weight: 4504,2

Shelf life (days): 1460

Notes: TIP39 is a neuropeptide and parathyroid hormone receptor type 2 (PTH2R) agonist.{51480} It induces cAMP accumulation in COS-7 cells expressing recombinant human or rat PTH2R (EC50s = 0.5 and 0.8 nM, respectively) and F-11 cells that endogenously express PTH2R (EC50 = 1.15 nM). TIP39 (1 nM) induces cell cycle arrest at the G0/G1 phase and decreases expression of the master regulator of cartilage differentiation Sox9 in CFK2 rat chondrocytes.{51481} TIP39 (100 pmol/animal) decreases immobility time in the forced swim test in mice.{51482}

• SKU: CAY37452-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37452-1
• Package Unit: 1 mg
• Quantity Unit: STK