Formulation: A crystalline solid
Formal Name: 4-[(5-methyl-3-isoxazolyl)methoxy]-5-(2-pyridinylmethyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine
Purity: ≥98%
Formula Markup: C17H16N6O2
Formula Weight: 336,4
Shelf life (days): 1460
CAS Number: 1642857-69-9
Notes: TLR agonist 2 is a toll-like receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) value of 0.4 μM in a cell-based reporter assay.{54116} It is selective for TLR7 over TLR8 (LEC = >100 μM). TLR7 agonist 2 (0.3-10 mg/kg) increases IFN-α levels and the IFN-stimulated gene (ISG) response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma. It increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys when administered at a dose of 10 mg/kg. TLR agonist 2 (0.3-5 mg/kg) reduces serum and liver viral load in the hydrodynamic injection (HDI) hepatitis B virus (HBV) mouse model.
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