Toceranib, CAS 356068-94-5

Formulation: A crystalline solid

Formal Name: 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide

Purity: ≥95%

Formula Markup: C22H25FN4O2

Formula Weight: 396,5

Shelf life (days): 1460

CAS Number: 356068-94-5

Notes: Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).{17826} It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.{17826} Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.{17826} It is active in vivo and is commonly used against solid tumors in dogs.{28879,28880}

• SKU: CAY17714-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17714-25
• Package Unit: 25 mg
• Quantity Unit: STK