Formulation: A solid
Formal Name: N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-6-(methyl-d3)-benzamide-2,3,4,5-d4
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C26H18ClD7N2O3
Formula Weight: 456
Shelf life (days): 1460
CAS Number: 1246818-18-7
Notes: Tolvaptan-d7 is intended for use as an internal standard for the quantification of tolvaptan (Item No. 19691) by GC- or LC-MS. Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.
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