Formulation: A solid
Formal Name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-benzamide, monohydrochloride
Purity: ≥95%
Formula Markup: C21H28N2O5 • HCl
Formula Weight: 424,9
Shelf life (days): 1460
CAS Number: 554-92-7
Notes: Trimethobenzamide is a dopamine D2 receptor antagonist and antiemetic.{41366} It prevents emesis induced by the dopamine agonist apomorphine (Item No. 16094) in dogs when used at a dose of 20 mg/kg and stimulates contraction of isolated guinea pig ileum (ED50 = 8.7 μg/mL).{41368} Trimethobenzamide (20 mg/kg) decreases apomorphine-induced pecking responses in pigeons by 20% and increases the latent period of pecking from 4.3 to 8 minutes.{41367} Trimethobenzamide (6.7 g/kg per day for 2 weeks) enhances compensation and decreases recovery time from 70 to 32 weeks in unilaterally labyrinthectomized cats, a model of vestibular injury.{41369} Formulations containing trimethobenzamide have been used to treat nausea and vomiting.
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