Formulation: A solid
Formal Name: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,2-dimethyl-N-(methyl-d3)propan-1-amine, (2Z)-2-butenedioate
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C20H23D3N2 • C4H4O4
Formula Weight: 413,5
Shelf life (days): 1460
Notes: Trimipramine-d3 (maleate) is intended for use as an internal standard for the quantification of trimipramine (maleate) (Item No. 15921) by GC- or LC-MS. Trimipramine is a tricyclic antidepressant.{25914,40358,30236} It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT; Kds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H1 receptor antagonist (Ki = 0.02 µM) that is selective for histamine H1 over H2, H3, and H4 receptors (Kis = 0.04, >100, and 43.6 µM, respectively).{25914,40358} Trimipramine binds to muscarinic acetylcholine and α1- and α2-adrenergic receptors (Kds = 58, 24, and 580 nM, respectively), as well as dopamine D1 and D2 receptors and 5-HT receptor subtypes 5-HT1C and 5-HT2 (Kis = 346.7, 57.5, 537, and 19.5 nM, respectively).{25914,30236} It reduces immobility time in the forced swim test in rats when administered at a dose of 10 mg/kg.{59740} Formulations containing trimipramine have previously been used in the treatment of depression.
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