Product Type: Agonist
CAS No.: 71441-28-6
MolecularFormula: C24H28O2
Molecular Weight: 348,5
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (4 mg/ml)
Appearance: Off-white powder
PubChem CID: 5289501
Scientific Background: TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors (1). Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Tranylcypromine, Valproic Acid, 3-Deazaneplanocin A, and E-616452 (2). And it Induces the in vitro growth and differentiation to granulocytes of myeloid progenitors isolated from myelodysplastic syndrome (MDS) patients (3).
References: 1. Beard R.L., et al. (1995) J Med Chem. 38 (15): 2820-2829. 2. Hou P. et al. (2013) Science. 341 (6146): 651-654. 3. Fabian I. (1987) Leukemia Research. 11 (7): 635-640.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
