Formulation: A solid
Formal Name: (2β,3β,5β,11α,22R)-2,3,11,14,20,22,25-heptahydroxy-cholest-7-en-6-one, hydrate
Purity: ≥95%
Formula Markup: C27H44O8 • XH2O
Formula Weight: 496,6
Shelf life (days): 1460
Notes: Turkesterone is a phytoecdysteroid that has been found in A. turkestanica and has diverse biological activities.{58595} It binds to the ecdysteroid receptor (KD = 0.491 µM for the C. tentans receptor) and induces pupariation in G. mellonella, S. bullata, and D. vulpinus last instar larvae (ED50s = 10, 0.03, and 0.2 µg/larvae, respectively).{58596,58597} Turkesterone scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 140.92 µg/ml) and is cytotoxic to HeLa cervical, HepG2 hepatic, and MCF-7 breast cancer cells (IC50s = 75.2, 63.01, and 105.2 µg/ml, respectively).{58595} It decreases serum glucose levels and increases serum insulin and C-peptide levels in a rat model of diabetes induced by alloxan (Item No. 9002196) when administered at a dose of 10 mg/kg.{58598} Turkesterone prevents immobilization stress-induced stomach ulcers in mice.{58599}
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