Formulation: A lyophilized powder
Formal Name: N-L-tyrosyl-α-calcitonin gene-related peptide (human), trifluoroacetate salt
Purity: ≥95%
Formula Markup: C172H276N52O51S2 • XCF3COOH
Formula Weight: 3952,5
Shelf life (days): 1460
CAS Number: 124756-98-5
Notes: Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; Item No. 24405).{38807} It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).{38808} Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).{38807} It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).{38809}
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