Formulation: A solid
Formal Name: benzenedecanoic acid, (1S)-1-(bromomethyl)-2-(phosphonooxy)ethyl ester, monoammonium salt
Purity: ≥95%
Formula Markup: C19H29BrO6P • NH4
Formula Weight: 482,4
Shelf life (days): 1460
Notes: UCM-05194 is an agonist of lysophosphatidic acid receptor 1 (LPA1).{59242} It induces calcium mobilization in RH7777 cells expressing LPA1 (EC50 = 0.24 µM). It is selective for LPA1 over LPA2 and LPA3 at 10 µM and is 10-fold selective over LPA5 and 50-fold selective over LPA4, LPA6, and autotaxin. UCM-05194 (1 µM) induces neurite retraction in, and migration of, B103 rat neuroblastoma cells overexpressing LPA1. It induces receptor internalization and neuronal desensitization in the same cells when used at a concentration of 1 µM and reduces the firing activity of primary rat neonatal dorsal root ganglia (DRG) neurons with repeated application at 10 µM. UCM-05194 (10 mg/kg) reduces acetic acid-induced writhing and hind paw mechanical hypersensitivity in mice.
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