UoS 12258, CAS 875927-64-3

Formulation: A solid

Formal Name: N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

Purity: ≥98%

Formula Markup: C17H19FN2O2S

Formula Weight: 334,4

Shelf life (days): 1460

CAS Number: 875927-64-3

Notes: UoS 12258 is a positive allosteric modulator of AMPA receptors.{68091} It potentiates glutamate-induced currents in HEK293 cells expressing human ionotropic glutamate receptor 2 (GluR2) homomeric AMPA receptors (EC50 = 2.51 µM), as well as HEK293 cells expressing GluR1, GluR3, or GluR4 homomeric AMPA receptors. UoS 12258 (0.3 and 1 mg/kg) increases novel object exploration in a novel object recognition test in rats. It also reduces escape latencies in the Morris water maze in aged rats.

• SKU: CAY36571-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36571-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe