Formulation: A crystalline solid
Formal Name: uridine 5′-(tetrahydrogen triphosphate), trisodium salt
Purity: ≥95%
Formula Markup: C9H12N2O15P3 • 3Na
Formula Weight: 550,1
Shelf life (days): 1460
CAS Number: 19817-92-6
Notes: UTP is a nucleotide and dual agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors).{53844,53845} It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM).{53845} UTP stimulates proliferation of PANC-1 cells (EC50 = 13.1 μM), an effect that can be prevented by siRNA against the P2Y2 receptor.{53844} It induces vasoconstriction in perfused isolated canine epicardial coronary artery in a concentration-dependent manner.{53846} UTP is formed from uridine monophosphate (UMP) by two sequential phosphorylations and can be converted to cytidine 5'-triphosphate (CTP; Item No. 18147).{53847} It also reacts with glucose-1-phosphate (Item No. 30566) to form UDP-glucose (Item No. 15602), a precursor in the biosynthesis of glycogen.{52573}
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