Formulation: A lyophilized powder
Formal Name: L-phenylalanyl-L-threonyl-L-leucyl-L-seryl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-isoleucyl-L-methionyl-L-asparaginyl-L-leucyl-L-leucyl-L-phenylalanyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-asparaginyl-L-leucyl-L-arginyl-L-alanyl-L-glutaminyl-L-alanyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-histidyl-L-leucyl-L-methionyl-L-alanyl-L-glutaminyl-L-isoleucinamide, 2,2,2-trifluoroacetate
Purity: ≥95%
Formula Markup: C185H307N53O50S2 • XCF3COOH
Formula Weight: 4137,9
Shelf life (days): 1460
CAS Number: 357952-09-1
Notes: Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin (Item No. 24745), urocortin II (Item No. 24746), frog sauvagine, and piscine urotensin I.{39576} Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III (Item Nos. 24749 / 24750), mouse urocortin II (Item No. 24747), human urocortin (Item No. 24744), and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively). It stimulates cAMP production in CHO cells expressing rat CRF2α and mouse CRF2β (EC50s = 0.16 and 0.12 nM, respectively) as well as cultured anterior pituitary cells expressing endogenous CRF2β. Urocortin III is co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic β-cells.{39579} In vivo, urocortin III reduces food intake in a dose- and time-dependent manner in mice with a minimum effective dose (MED) of 0.3 nmol/animal.{41572} It increases swimming time in a forced swim test in mice, indicating antidepressant-like activity.{41573}
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