Formulation: A lyophilized powder
Formal Name: L-alanylglycyl-L-threonyl-L-alanyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (6→11)-disulfide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C62H84N14O17S2 • XCF3COOH
Formula Weight: 1361,5
Shelf life (days): 1460
Notes: Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki = 2.06 nM for the human recombinant receptor expressed in HEK293 cells).{7198} It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.{39612} Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across isolated goby posterior intestine in 5% seawater-adapted solution.{39613} In vivo, urotensin II (1.5-150 nmol/kg) decreases diastolic blood pressure and increases heart rate in anesthetized rats.{39614} It also reduces the pressor responses to sympathetic nerve stimulation, norepinephrine (Item No. 16673), and vasopressin in pithed rats when administered at a dose of 150 nmol/kg.
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