Formulation: A lyophilized powder
Formal Name: L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5→10)-disulfide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C64H85N13O18S2 • XCF3COOH
Formula Weight: 1388,6
Shelf life (days): 1460
Notes: Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).{7198} It increases intracellular calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM). Urotensin II increases the level of reactive oxygen species (ROS) in pulmonary artery smooth muscle cells and induces proliferation, an effect that is inhibited by depletion of NADPH oxidase subunits.{36499} Urotensin II potently induces contraction of isolated rat thoracic aorta with an EC50 of 0.8 nM.{7198} It also induces contraction of isolated cynomolgus monkey arterial, but not venous, vessels and, when administered at doses greater than 100 pmol/kg, can lead to severe myocardial depression and fatal circulatory collapse.
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