Formulation: A solid
Formal Name: L-histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-methylalanyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycyl-L-leucine
Purity: ≥98%
Formula Markup: C191H298N46O58
Formula Weight: 4166,7
Shelf life (days): 1460
CAS Number: 2460862-12-6
Notes: Utreglutide is a G protein-biased peptide agonist of glucagon-like peptide 1 receptor (GLP-1R).{69852} It selectively induces cAMP accumulation in HEK293 cells expressing human GLP-1R over β-arrestin recruitment in CHO-K1 cells expressing human GLP-1R (EC50s = 0.63 and 79 nM, respectively). Utreglutide induces insulin secretion in INS-1 832/3 rat insulinoma cells (EC50 = 6.3 nM). In vivo, utreglutide (1.5-6 nmol/kg) reduces food intake and body weight, increases plasma insulin levels, and decreases plasma glucose, hemoglobin A1c (HbA1c), glucagon, and triglyceride levels in diabetic db/db mice.
English
Deutsch
