Formulation: A solid
Formal Name: 4-[[1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-3-piperidinyl]methyl]-morpholine, monohydrochloride
Purity: ≥98%
Formula Markup: C20H25F3N4O2 • HCl
Formula Weight: 446,9
Shelf life (days): 1460
CAS Number: 2922283-73-4
Notes: V-0219 is a positive allosteric modulator (PAM) of the glucagon-like peptide 1 receptor (GLP-1R).{67722} It is selective for GLP-1R over a panel of 54 other receptors, ion channels, and transporters at 10 µM. V-0219 (0.001-1 nM) potentiates GLP-1-induced cAMP accumulation in HEK293 cells expressing human GLP-1R. It also potentiates GLP-1-induced insulin secretion in INS-1E rat insulinoma cells, an effect that can be blocked by the GLP-1R antagonist exendin (9-39) amide. V-0219 improves glucose tolerance in wild-type, but not Glp1r knockout, mice when administered at a dose of 0.1 mg/kg and enhances a reduction in food intake induced by the GLP-1R agonist exendin-4 in rats at 0.001 mg/kg.
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