Formulation: A solid
Formal Name: 6-[ethyl(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)amino]-3-pyridinecarboxylic acid
Purity: ≥98%
Formula Markup: C23H30N2O2
Formula Weight: 366,5
Shelf life (days): 730
CAS Number: 1807740-94-8
Notes: V-125 is an agonist of retinoid X receptors (RXRs).{62909} It induces homodimerization of RXR in HCT116 cells in a two-hybrid assay (EC50 = 13.8 nM). V-125 selectively induces transactivation of RXRα in human RXRα-overexpressing HCT116 cells over transactivation of RARα in human RARα-overexpressing HEK293 cells when used at concentrations of 25 and 100 nM, respectively. In vivo, V-125 (80 mg/kg in the diet) inhibits vinyl carbamate-induced lung tumor growth in mice.{62910} Unlike the RXR agonist bexarotene (Item No. 11571), V-125 does not increase plasma triglyceride or cholesterol levels in mice.
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