Formulation: A solid
Formal Name: 4-(5-(methyl-d3)-3-phenylisoxazol-4-yl)benzenesulfonamide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C16H11D3N2O3S
Formula Weight: 317,4
Shelf life (days): 730
CAS Number: 1219794-90-7
Notes: Valdecoxib-d3 is intended for use as an internal standard for the quantification of valdecoxib (Item No. 10006120) by GC- or LC-MS. Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM, for human recombinant COX-2 and COX-1, respectively).{42951} It decreases LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated human whole blood (IC50 = 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively).