Formulation: A solid
Formal Name: α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H29Cl2D4NO5 • C20H16O2
Formula Weight: 778,8
Shelf life (days): 1460
CAS Number: 2021249-10-3
Notes: Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol (Item No. 20702) by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).{32608} It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine (Item No. 33828) in guinea pigs when administered via nebulization (EC50 = 30 µM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
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