Formulation: A crystalline solid
Formal Name: 12-methoxy-ibogamine-18-carboxylic acid, methyl ester
Purity: ≥98%
Formula Markup: C22H28N2O3
Formula Weight: 368,5
Shelf life (days): 730
CAS Number: 510-22-5
Notes: Voacangine is an indole alkaloid that has been found in T. citrifolia, V. africana, V. obtusa, and T. iboga with diverse biological activities.{41758,41754} It inhibits the growth of M. tuberculosis, M. avium, and M. kansasii with MIC values of 50, >200, and 100 μg/mL, respectively.{41754} Voacangine (0.01-100 μM) dose-dependently reduces membrane currents in HEK293 cells expressing the hERG potassium channel and displaces the hERG ligand dofetilide (Item No. 15045) with a Ki value of 3.9 μM.{41755} Voacangine suppresses agonist-induced activation of transient receptor potential (TRP) channels with IC50 values of 50 and 9 μM for activation induced by the TRPV1 agonist capsaicin (Item No. 92350) and the TRPM8 agonist menthol, respectively.{41756} It also activates TRPA1 channels and stimulates calcium influx (IC50 = 8 μM in HEK293 cells expressing TRPA1), an effect that is blocked by the TRPA1 blocker HC-030031 (Item No. 11923). In vivo, voacangine (2 and 4 μg per egg) inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity.{41757}
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