Formulation: A crystalline solid
Formal Name: 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98%
Formula Markup: C18H19N3O2S
Formula Weight: 341,4
Shelf life (days): 1460
CAS Number: 409351-28-6
Notes: VU0152100 is a positive allosteric modulator of M4 muscarinic acetylcholine receptors.{61171} It potentiates calcium mobilization induced by acetylcholine (ACh) in CHO-K1 cells expressing the rat M4 receptor with an EC50 value of 380 nM. VU0152100 is selective for M4 over M1, M2, M3 and M5 receptors, as well as a panel of 68 additional GPCRs, ion channels, transporters, and enzymes, but does bind to the benzodiazepine binding site of the GABAA receptor at 10 µM. It reduces cocaine-induced increases in locomotor activity and cocaine self-administration in mice when administered at a dose of 1 mg/kg.{61172}
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