Formulation: A solid
Formal Name: 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity: ≥98%
Formula Markup: C17H12F3NO4
Formula Weight: 351,3
Shelf life (days): 1460
CAS Number: 1160247-92-6
Notes: VU0238429 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs; EC50 = 1.16 µM in a calcium mobilization assay).{60969} It is selective for M5 mAChRs over M1, M2, M3, and M4 mAChRs in CHO cells expressing the human receptors (EC50s = >30 µM for all in calcium mobilization assays). VU0238429 (10 mg/kg) reduces head-twitch behavior induced by the serotonin (5-HT) receptor subtype 5-HT2A agonist DOI in mice.{60970} It reverses MK-801-induced memory deficits in the novel object recognition test in mice when administered alone or in combination with the GABAB receptor positive allosteric modulator GS-39783 (Item No. 29482).
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