Notes: VU0365114 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs).{57765} It increases ACh-induced calcium mobilization in CHO cells expressing human M5 mAChRs (EC50 = 2.7 µM) selectively over CHO cells expressing human M1-4 mAChRs (EC50s = >30 µM for all).