Formulation: A solid
Formal Name: 2-cyclopentyl-2,9-dihydro-9-methyl-N-[[(2S)-1-(1-methylethyl)-2-pyrrolidinyl]methyl]-1-oxo-1H-pyrido[3,4-b]indole-4-carboxamide, monohydrochloride
Purity: ≥98%
Formula Markup: C26H34N4O2 • HCl
Formula Weight: 471
Shelf life (days): 1460
Notes: VU0453379 is an allosteric agonist and positive allosteric modulator (ago-PAM) of glucagon-like peptide 1 receptor (GLP-1R).{72528} It induces calcium mobilization in 9-3-H cells expressing human GLP-1R (EC50 = 1.3 µM) and enhances GLP-1-, exenatide-, or liraglutide-induced calcium mobilization in the same cells (EC50s = 1.8, 8.4, and 30 µM, respectively). VU0453379 (30 µM) potentiates exenatide-induced insulin secretion in primary mouse pancreatic islets. It reverses catalepsy induced by haloperidol (Item No. 12014) in a rat model of Parkinson’s disease motor symptoms when administered at a dose of 30 mg/kg.
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