VU0469650 (hydrochloride)

Formulation: A solid

Formal Name: 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile, monohydrochloride

Purity: ≥98%

Formula Markup: C22H28N4O • HCl

Formula Weight: 401

Shelf life (days): 1460

Notes: VU0469650 is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 1 (mGluR1).{54670} It inhibits glutamate-induced calcium flux in cells expressing human mGluR1 (IC50 = 99 nM). VU0469650 is greater than 100-fold selective for mGluR1 over mGluR2-8 at 10 µM.

• SKU: CAY32933-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32933-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK