Formulation: A solid
Formal Name: (S)-3-chloro-N-(2-(4-(2-cyanophenyl)-2-methylpiperazin-1-yl)ethyl)-4-fluorobenzenesulfonamide, monohydrochloride
Purity: ≥95%
Formula Markup: C20H22ClFN4O2S • HCl
Formula Weight: 473,4
Shelf life (days): 1460
Notes: VU6036720 is an inhibitor of heteromeric inward-rectifier potassium channels (Kir) composed of Kir4.1 and Kir5.1 subunits (IC50 = 0.24 µM).{69671} It is selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv11.1, also known as human ether-a-go-go (hERG; IC50 = 6.4 µM). VU6036720 (30 and 100 mg/kg) does not inhibit diuresis in mice due to low oral bioavailability and high hepatic clearance.
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