VUF 5574, CAS 280570-45-8

Formulation: A solid

Formal Name: N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-urea

Purity: ≥98%

Formula Markup: C21H17N5O2

Formula Weight: 371,4

Shelf life (days): 1460

CAS Number: 280570-45-8

Notes: VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor).{49476} It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine (Item No. 21232) in isolated porcine coronary artery smooth muscle cells.{49477} It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM.{49478} VUF 5574 (2 µg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.{49479}

• SKU: CAY27676-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27676-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK