Formulation: A crystalline solid
Formal Name: carbamimidothioic acid, 2-[(aminoiminomethyl)amino]ethyl ester, dihydrobromide
Purity: ≥95%
Formula Markup: C4H11N5S • 2HBr
Formula Weight: 323,1
Shelf life (days): 1460
CAS Number: 100130-32-3
Notes: VUF8430 is a histamine H4 receptor agonist (Ki = 31.6 nM).{53487} It is selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 µM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8). VUF8430 inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC50 = 50.1 nM). In vivo, VUF8430 (30 mg/kg) enhances HCl-induced formation of gastric lesions in rats.{51085} It also reduces mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI).{53488}
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