Formulation: A crystalline solid
Formal Name: (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamide
Purity: ≥98%
Formula Markup: C18H27NO2
Formula Weight: 289,4
Shelf life (days): 1460
CAS Number: 68489-09-8
Notes: WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8).{45846} It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 µM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin (Item Nos. 92350 / 10010743) in wild-type, but not Trpm8-/-, mice.{45847} It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.