Formulation: A crystalline solid
Formal Name: 1,2,3,6-tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine, monohydrochloride
Purity: ≥98%
Formula Markup: C24H22F3N • HCl
Formula Weight: 417,9
Shelf life (days): 1460
CAS Number: 90494-79-4
Notes: Xaliproden is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 4.3 nM in a radioligand binding assay).{59032} It is selective for 5-HT1A over 5-HT2 and α1-adrenergic receptors (IC50s = 697 and 630 nM, respectively), as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s = ≥10 µM for all) but also binds sigma (σ) receptors (IC50 = 73 nM). Xaliproden (250 nM) increases NGF-induced neurite outgrowth and α-actinin levels in PC12 cells.{59033} It decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by four-vessel occlusion (4-VO) and sciatic nerve crush injury, respectively, when administered at a dose of 10 mg/kg per day.{59034} Xaliproden (10 mg/kg per day) inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein.{59035}
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