Formulation: A crystalline solid
Formal Name: N-[2-[[2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-4-morpholinecarboxamide, (E)-2-butenedioate (2:1)
Purity: ≥98%
Formula Markup: C16H25N3O5 • 1/2C4H4O4
Formula Weight: 397,4
Shelf life (days): 1460
CAS Number: 73210-73-8
Notes: Xamoterol is a partial agonist of β1-adrenergic receptors (β1-ARs) with an EC50 value of 80 nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures.{41648} It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM).{41649} In vivo, xamoterol increases heart rate in beagle dogs (ED50 = 3.2 µg/kg) and in a rat model of spontaneous heart failure (ED50 = 6 µg/kg), an effect that is reversed by the selective β1-AR antagonist betaxolol (Item No. 18625) but not the selective β2-AR antagonist ICI 118551 (Item No. 15591).{41648,41647} Formulations containing xamoterol have been used in the treatment of heart failure.
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