Formulation: A crystalline solid
Formal Name: 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-benz[7,8]indolizino[2,3-b]quinoxaline
Purity: ≥98%
Formula Markup: C22H21N3O2
Formula Weight: 359,4
Shelf life (days): 1460
CAS Number: 163769-88-8
Notes: YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 µM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay.{40323} It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 µM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.{40324,40325}
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